Lexus ES Door Lock Failure

Sounds familiar. I had almost the exact same problem with my old BMW 3 Series a few years back. The central locking just gave up. Are you sure it's all doors affected? Did you check the fuses already?

Yes, it's affecting all the doors simultaneously, so I suspect a central issue rather than individual door sensors. Yes, I've checked the fuses – all seem to be in good nick. Did your BMW act up the same way, all doors at once? What was it in your case?

Yep, same symptoms – all doors went kaput at the same time. I initially thought it was the remote, but the key wasn't working either. Eventually, it turned out to be a broken wire in the door harness where it passes from the car body into the door. Constant opening and closing had fatigued the wire until it snapped. I'd suggest taking it to a trusted workshop. They'll have the right tools and experience to diagnose it properly before you accidentally cause more damage.

A broken wire in the door harness sounds like a very plausible culprit. I appreciate the advice, and I think you're right – I'll take it to my local Lexus mechanic. They diagnosed it as a defective cable connection. The repair cost was 95€.